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We also currently have one. Specializing in treatment of metastases. Weichselbaum treats patients at The University of Chicago in Hyde Park. Chmura is the Residency Program Director. Chmura treats patients at The University of Chicago in Hyde Park. Curriculum vitae. Clinical Interests. Golden treats patients at our Silver Cross clinic. Curriculum vitae. Electron Paramagnetic Resonance Oxygen Imaging. Clinical Interests: Imaging oxygen, physiology of tumors. Halpern treats patients at our UIC clinic. Curriculum vitae. Clinical Interests: Diseases of the esophagus, head and neck cancer, prostate cancer, lung cancer, mediastinal tumors, general radiation oncology. Haraf treats patients at The University of Chicago in Hyde Park. Curriculum vitae. Clinical Interests: Breast cancer, gynecologic cancers, adult lymphoma, general radiation oncology. Hasan treats patients at The University of Chicago in Hyde Park. Curriculum vitae. Clinical Interests: breast cancer, gynecologic cancer, general radiation oncology. Howard treats patients at our UIC clinic. Curriculum vitae. Clinical Interests: Intensity modulated radiation therapy, stereotactic ablative radiation therapy, general radiation oncology. Koshy treats patients at our UIC clinic. Curriculum vitae. Clinical Interests: Genitourinary cancer, gastrointestinal cancer, prostate brachytherapy, clinical trials. Liauw treats patients at The University of Chicago in Hyde Park. Curriculum vitae. Clinical Interests: Lung cancer, mesothelioma, mediastinal tumors, gastrointestinal cancer, stereotactic ablative radiotherapy, intensity modulated radiation therapy, general radiation oncology. Malik treats patients at The University of Chicago in Hyde Park. Curriculum vitae. Clinical Interests: Breast cancer, gynecologic cancer. Mc. Call treats patients at our Silver Cross clinic. Curriculum vitae. Clinical Interests: Brain and spine tumors, bladder cancer, radiosurgery, stereotactic body radiotherapy, image- guided radiation therapy, translational oncology, and molecular mechanisms of cancer. Pitroda treats patients at The University of Chicago in Hyde Park. Curriculum vitae. Clinical Interests: Lung, gynecologic, and breast cancers. Son treats patients at our UIC clinic and at The University of Chicago in Hyde Park. ![]() Curriculum vitae. Clinical Interests: Head and neck cancer, HPV- positive cacners, general radiation oncology. Spiotto treats patients at our UIC clinic. ![]() Nakamura has been making important contributions to the fields of genomic medicine and cancer research for nearly three decades. He is one of the pioneers of applying genetic variations (VNTR and RFLP markers) and genomics approach to the medical field. DNA polymorphic markers developed by his group in the laboratory of Professor Ray White at the University of Utah had made it possible to map and clone genes responsible for hereditary diseases. Using these DNA markers and genetic maps, many scientists around the world had been able to show the usefulness of the reverse genetic method. In fact, many genes responsible for hereditary diseases were mapped and cloned by the use of the DNA markers and chromosomal maps developed in the White laboratory. Such discoveries include genes responsible for neurofibromatosis type 1, familial polyposis coli, multiple endocrine neoplasia type 1, familial breast cancer, and ataxia telangiectasia etc. O\'Connell, Roger Wolff, T. ![]() White: Variable number of tandem repeat (VNTR) markers for human gene mapping. Science, 2. 35: 1. C. Nordenskjold: Multiple endocrine neoplasia type 1 gene maps to chromosome 1. Nature, 3. 32: 8. D. Skolnick: Gene for von Recklinghausen neurofibromatosis is in the pericentromeric region of chromosome 1. Science, 2. 36: 1. Cancer Biology Research Program. A clinical trial is one of the final stages of a long and. Participating in clinical trials at the University of Illinois Cancer Center means that you will. At the University of Chicago Medicine. A Dedicated Program for All Breast Cancer Needs. Breast Cancer Clinical Trials.
![]() B. White: Allelotype of colorectal carcinomas. Science, 2. 44: 2. ![]() B. Bos: Genetic alterations during colorectal tumor development. Med., 3. 19: 5. 25- 5. R. A. Yoder: Localization of ataxia- telangiectasia gene to chromosome 1. Nature, 3. 36: 5. S. Hamilton: Allelic loss in colorectal carcinoma. JAMA, 2. 61: 3. 09. M. White: Mapping of the seizure gene: Benign familial neonatal convulsions linked to genetic makers on chromosome 2. Nature, 3. 37: 6. K. White: Amplification of a VNTR locus (p. MCT1. 18) by the polymerase chain reaction (PCR) and its application to forensic science. Forensic Sci., 3. T. Nakamura: Allelotype of breast cancer: Cumulative allele losses promote tumor progression in primary breast cancer. Cancer Research, 5. Bert Vogelstein at Johns Hopkins Medical Center in Baltimore, MD, and was able to identify an APC gene that is responsible for familial adenomatous polyposis coli (FAP) and characterized the germline mutations in FAP patients. Nakamura: Identification of FAP locus genes from chromosome 5q. Science, 2. 53: 6. I. Vogelstein: Mutations of chromosome 5q. FAP and colorectal cancer patients. Science, 2. 53: 6. Y. Nakamura: Somatic mutation of the APC gene in colorectal tumors: mutation cluster region in the APC gene. Human Molecular Genetics, 1: 2. Y. Nakamura: Germ- line mutations of the APC gene in 5. USA, 8. 9: 4. 45. H. Noda: Rapid colorectal. Science, 2. 78: 1. Toda: An ancient retrotransposal insertion causes Fukuyama- type congenital muscular dystrophy (FCMD). Nature, 3. 94: 3. A. Ikegawa: Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine. Nature Genetics, 1. M. Nakamura: Identification of the gene responsible for gelatinous drop- like corneal dystrophy. Nature Genetics, 2. T. Matsumoto: Heterozygous TGFBR2 mutations in Marfan syndrome. Nature Genetics, 3. Nakamura group reported dozens of genes playing key roles in many cancer types through extensive expression profile analysis and subsequent functional analysis of gene products. An example of a group of genes involved in development and progression of human cancer is the protein methyltransferases including SMYD3 and SUV3. H2. In addition, his group has reported on many genes that are involved in the p. BAI1, p. 53. R2, p. AIP1, p. 53. DINP1, p. RDL, and PADI4. These genes play critical roles in p. DNA repair, angiogenesis, protein modification, and apoptosis. Furthermore, his group also reported a number of genes involved in the b- catenin- TCF pathway including the first mutation detection in the AXIN1 gene. Nakamura: Activation of the beta- catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3. Cancer Research, 5. S. Nakamura: AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus- mediated transfer of AXIN1. Nature Genetics, 2. K. Taya: p. 53. AIP1, a potential mediator of p. Ser- 4. 6- phosphorylated p. Cell, 1. 02: 8. 49- 8. H. Nakamura: A ribonucleotide reductase gene involved in a p. DNA damage. Nature, 4. H. Nakamura: Genome- wide analysis of gene expression in human hepatocellular carcinomas using c. DNA microarray: identification of genes involved in viral carcinogenesis and tumor progression. Cancer Research, 6: 2. C. Arakawa: p. 53. RDL1 regulates p. Nature Cell Biology, 5: 2. T. Arakawa: Impaired function of p. R2 in Rrm. 2b- null mice causes severe renal failure through attenuation of d. NTP pools. Nature Genetics, 3. R. Nature Cell Biology, 6: 7. C. Matsuda: Regulation of histone modification and chromatin structure by the p. PADI4 pathway. Hamamoto: Enhanced HSP7. B. Nature Communications, 3: DOI: 1. K. Hamamoto Critical role of lysine 1. H2. AX for g- H2. AX production and DNA repair. Nature Communications, 5: DOI: 1. R. Nakamura: Critical roles of non- histone protein lysine methylation in human tumorigenesis. Contribution to the International Hap. Map project as well as leading Biobank Japan project and GWAS and pharmacogenomics studies. In 2. 00. 0- 2. 01. Japanese SNP project in the Japanese Millennium genome project, the Japanese group of the International Hap. Map project, as well as the Biobank Japan and pharmacogenomics project. Nature, 4. 37: 1. The International Hap. Map Consortium: The International Hap. Map Project. Nature, 4. The International Hap. Map Consortium: A second generation human haplotype map of over 3. SNPs. Nature, 4. 49: 8. K. Tanaka: Functional SNPs in the lymphotoxin- . Nature Genetics, 3. A. Nakayama- Hamada, R. Kawaida, M. Yamamoto: Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis. Nature Genetics, 3. S. Nakamura: A genome- wide association study identifies genetic variants in the CDKN2. BAS locus associated with endometriosis in Japanese. Daigo: Variation in TP6. Japanese and Korean population. Nakamura: A genome- wide association study identifies three loci associated with susceptibility to uterine fibroids. Nature Genetics, 4. S. Kubo: Genome- wide association study identifies two susceptibility loci for exudative age- related macular degeneration in the Japanese population. Development of anti- cancer drugs (cancer peptide vaccines, antibody drugs and small molecular compounds)Dr. Using such information, his group has developed two monoclonal antibodies, one against FZD1. CDH3 that was expressed in many types of cancer. The phase I clinical trial for synovial sarcoma using 9. Y- conjugated anti- FZD1. MELK is a protein that was implied its involvement in the maintenance of tumor- initiating cells. TOPK plays a critical role at the final step of cytokinesis.(1) C. Katagiri: Radioimmunotherapy of human synovial sarcoma using a monoclonal antibody against FZD1. Cancer Science, 9. H. Endo: In vivo therapeutic effect of CDH3/P- cadherin- targeting radioimmunotherapy. Cancer Immunology, Immunotherapy, 6. Matsuo: Development of an orally- administrative MELK- targeting inhibitor that suppresses the growth of various types of human cancer Oncotarget, 3: 1. Y. Shinohara: Phase II clinical trial of multiple peptide vaccination for advanced head and neck cancer patients revealed induction of immune responses and improved OS. Clinical Cancer Research, 1. DOI: 1. 0. 1. 15. CCR- 1. 4- 0. 20. H. Nakamura: Preclinical efficacy of Maternal Embryonic Leucine- zipper Kinase (MELK) Inhibition in Acute Myeloid Leukemia. Oncotarget, 5: 1. Y. Alachkar, and Y Nakamura: TOPK inhibitor induces complete tumor regression in xenograft models of human cancer through inhibition of cytokinesis. Science Translational Medicine, 2. Oncoimmunogenomics/Immunopharmacogenomics. Molecular changes in immune cells associated with disease conditions have not been analyzed in depth. It is obvious that our immune system plays a critical role in various biological and pathological conditions, such as infection, autoimmune diseases, drug- induced skin and liver toxicities, food allergy and rejection of transplanted organs. The recent development of cancer immunotherapies clearly demonstrates the importance of host immune cells, particularly drugs modulating the immune checkpoint molecules, in the fight against cancer. However, the molecular mechanisms by which these new therapies kill tumor cells still remain unclear. This new field has enormous potential to help us better understand the changes/alterations to our immune responses during the course of various disease conditions. Here we report the deep sequencing of T- cell and B- cell receptors that will enable us to capture the molecular contribution of the immune system which we believe plays a critical role in the pathogenesis of disease.(1) H. Nakamura: Quantitative T cell repertoire analysis by deep c. DNA sequencing of T cell receptor a and b chains using next- generation sequencing (NGS). Onco. Immunology, DOI: 1. X. Kline: Highly clonal T cell receptor repertoire among regulatory T cells in follicular lymphoma tissues . Kiyotani: Characterization of T cell repertoire in tumor tissues and blood in advanced colorectal cancers through deep T cell receptor sequencing. Oncology Letters, in press, 2. P. Y. Nakamura: Quantitative characterization of T cell repertoire in allogeneic hematopoietic stem cell transplant recipients. Park: Characterization of T cell repertoire of blood, tumor and ascites in ovarian cancer patients using next generation sequencing. Onco. Immunology, DOI: 1. X. 2. 01. 5. 1. 03. Dr. These articles include: 3. American Journal of Human Genetics, 1. Cancer Research, 6 articles in Lancet, 1. Nature, 2 articles in Nature Cell Biology, 7. Nature Genetics, 4 articles in Nature Communications, 7 articles in The New England Journal of Medicine, 1. Science and one article in Science Translational Medicine.
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